منابع مشابه
Inspiratory muscle training in exercise-induced paradoxical vocal fold motion.
The purpose of the study was to determine if inspiratory muscle training (IMT) would result in increased inspiratory muscle strength, reduced perception of exertional dyspnea, and improved measures of maximal exercise effort in an athlete with exercise-induced paradoxical vocal fold motion (PVFM). The participant, an 18-year-old woman, had a 2-year history of acute dyspnea with exertion during ...
متن کاملTo fold, first unfold
The double-ringed GroEL chaperone complex is well-known for capturing partially folded proteins and confi ning them within its central cavity to facilitate folding. GroEL is especially important to proteins that have a complex folding pattern, such as Rubisco. A prominent model of GroEL function suggests that the chaperone fi rst partially unfolds its substrate, disrupting misfolded and inhibit...
متن کاملFrom fold to function.
A number of recent advances have been made in deriving function information from protein structure. A fold relationship to an already characterized protein will often allow general information about function to be deduced. More detailed information can be obtained using sequence relationships to already studied proteins. Methods of deducing function directly from structure, without the use of e...
متن کاملDesign of the Comprehensive Fold Recognition Benchmark. Application to SeqFold, Training and Validation
Recent exponential increase of protein sequences creates a challenge for automated annotation methods. When sequence based methods (e.g. PSIBLAST [1]) fail to identify a possible homologue (generally below 25% of protein identity i.e. within so-called twilight zone), fold recognition methods offers additional sensitivity [2,4,5,8]. However, training, validating and comparing fold recognition pe...
متن کاملSensitivity of Superfolder GFP to Ionic Agents
Superfolder variant of the green fluorescent protein (sfGFP) became a favorite probe for examination of the unfolding-refolding processes of fluorescent proteins with beta-barrel structure owing to its reversible unfolding in comparison with other fluorescent proteins. Its benefit is the proper folding even in fusion constructions with poorly folded polypeptides. We noticed that guanidine thioc...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2006
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth0206-76